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It is important to treat the correct branch of the trigeminal nerve involved in the pain, to avoid excessive numbness post-procedure

van der Post RS, Vogelaar IP, et al

Rarely, it can cause scarring

The gradient starts from 97% A and hold for 0.5 min then decreased to 2% in 0.3 min, hold the 98% B for 0.4 min then returned to 97% A in 0.1 min and equilibrated for 0.7 min for waiting another injection

The results showed that 80.03% of the PDGF-BB in the hydrogel matrix was released within the first 7 d, while the BMP-2 adsorbed onto the nanosheet was released more slowly, with 74.51% of the loaded BMP-2 being released after 35 d [313]